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Sunday, July 12, 2020 | History

3 edition of Animal Models in Liver Research found in the catalog.

Animal Models in Liver Research

Volume 37 (Advances in Veterinary Medicine)

by Charles E. Cornelius

  • 211 Want to read
  • 33 Currently reading

Published by Academic Press .
Written in English


The Physical Object
Number of Pages512
ID Numbers
Open LibraryOL7325374M
ISBN 100120392372
ISBN 109780120392377

Abstract. Alcoholic liver disease (ALD) is a multifactorial lifestyle disease with enormous medical, economic, and social burdens to the world. Like other debilitating chronic inflammatory diseases, only a fraction of affected individuals develops advanced disease such as chronic alcoholic steatohepatitis, alcoholic neutrophilic hepatitis, cirrhosis, and liver : Jun Xu, Hidekazu Tsukamoto.   Liver fibrosis is defined as excessive extracellular matrix deposition and is based on complex interactions between matrix-producing hepatic stellate cells and an abundance of liver-resident and infiltrating cells. Investigation of these processes requires in vitro and in vivo experimental work in animals. However, the use of animals in translational research will be increasingly challenged Cited by:

  Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer worldwide. In this Review Yan Li, Zhao-You Tang and Jin-Xuan Hou provide an overview of animal models that are Cited by:   Heindryckx F, Colle I, Van Vlierberghe H () Experimental mouse models for hepatocellular carcinoma research. Int J Exp Pathol 90(4)– doi: /jx PubMedCentral PubMed CrossRef Google ScholarCited by:

Currently available animal models for NASH are of value for investigating some specific issues of disease progression, but none of them alone reflects the natural etiology and pathology of human fatty liver disease. Those animal models have been extensively reviewed by others (3, 39, 59, 99, , , , ), and thus only the most commonly Cited by:   Animal Model with “Humanized” Liver Predicts Drug Toxicity in Human Livers Research Update Ap Scientists have enlisted a special type of mouse with human cells in its liver for a proof of concept study to predict which experimental drugs can cause liver failure and should thus not be tested in humans.


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Animal Models in Liver Research by Charles E. Cornelius Download PDF EPUB FB2

The books contains a wide variety of animal models, including squirrel monkeys, gunn rats, lampres, horses, and chickens, to make this a truly comparative synthesis. Key Features * Important topics of animal research that have lead to breakthroughs in understanding human diseases.

(cont.) Animal models of liver fibrosis / Marcos Rojkind and Patricia Greenwel --Animal models of copper toxicosis / Michael L.

Schilsky and Irmin Sternlieb --Animal models in liver research: iron overload / Theodore C. Iancu --Portosystemic hepatic encephalopathy related with congenital and acquired hepatopathies in the dog / Jan Rothuizen.

This volume is a comprehensive survey and update of liver models used today by researchers on animal and human liver function and disease.

Important topics of animal research that are in this book and that have leadto breakthroughs in understanding human disease include cholesteral and bile pigment gallstones; alcoholic hepatopathy; neonatal jaundice; and : Hardcover.

To understand the cellular mechanisms of HCC, and to develop novel therapeutic options for HCC, a number of animal models have been developed over the years. These include rodent, rabbit, swine, and primate model by: 1. [Show full abstract] brief review provides an overview of the animal models currently available for translational liver cancer research, including rodent, rabbit, non-human primate, and pig models.

Over the last five decades, many animal models that have been useful for the study of ALD pathogenesis have been developed. Recently, a chronic-plus-binge ethanol feeding model was. CONCLUSION: A novel animal model of human liver cancer metastasis was established using the uPA/SCID mouse line.

This model could be useful for in vivo testing of anti-cancer drugs and for studying the mechanisms of human liver cancer by: 7. The etiologic complexity of AMD is reflected by the paucity of animal models that entirely replicate the human disease.

In this review, we compare the salient anatomy of the primate and rodent retina, particularly in the light of AMD pathology. Next, prevailing hypotheses explaining how AMD may develop are. Animal Models in Exosomes Research: What the Future Holds.

By Bárbara Adem and Sónia A. Melo. Submitted: chemioluminescence was mainly detected in the liver and the lungs, 4 h post-injection, a strong signal was only detected in the lungs. Help us write another book on Author: Bárbara Adem, Sónia A. Melo. Animal models of nonalcoholic fatty liver disease.

Lionel Hebbard Lionel Hebbard undertook undergraduate study at Griffith University and The University of Queensland, Australia, and completed his PhD on the role of CD44 in mammary gland development at The Institute of Genetics, University of Karlsruhe, by: Introduction.

Liver fibrosis represents a classical outcome of many chronic liver diseases irrespectively of the aetiology of injury. It results from successive rounds or chronic activation of the physiological wound healing response that sustains persistent fibrogenesis and leads to progressive fibrosis of the models have been used for several decades to study fibrogenesis and Cited by: Animal models are indispensable for the elucidation of pathogenesis mechanisms, the identification of potential therapeutic targets, and the development of novel therapies for various liver diseases.

Although large animals, including nonhuman primates, have occasionally been Cited by: 1. This review examines and critically appraises the various approaches to the study of acute hepatic failure in animal models, including both surgical and pharmacological approaches.

Keywords: liver failure, animal models, paracetamol, galactosamine, thioacetamide, carbon tetrachloride, hepatectomy, concanavalin A, lipopolysaccharideCited by: the most frequently used animal models in NAFLD research and serves as a starter’s guide to choose a model, focusing on each model’s major phenotypical features.

The use of animal models is crucial for determining mechanisms underlying initiation, progression, and resolution of fibrosis and for developing novel therapies. To date, no animal model can recapitulate all the hepatic and extra-hepatic features of liver disease.

In this review, we will discuss the current rodent models of liver by: Nevertheless, traditional and new promising animal models that mimic certain attributes of chronic liver diseases are established and being used to deepen our understanding in the underlying.

Thus it is likely that animal models will continue play a critical role in translational research and advancement of human and animal health.

Biography Aaron C. Ericsson, DVM, PhD, Marcus J. Crim, DVM, and Craig L. Franklin, DVM, PhD, are in the Mutant Mouse Regional Resource Center, Comparative Medicine Program and Department of Veterinary Pathobiology, University of Missouri.

With advances in molecular and genomic research offering novel insights into cardiovascular diseases, recently many transgenic animal models have been developed and characterized. Currently, more than 90% of all laboratory animals are mice and rats.

HCV animal models and liver disease Article (PDF Available) in Journal of Hepatology 61(1) November with Reads How we measure 'reads'. Several rodent models of liver injury associate with a DR and are instrumental to study the LPC response and its implication in liver regeneration and wound healing.

These models, as in human liver diseases, exhibit a large variety of DR/LPC patterns with different morphological features, kinetics of response, and differentiation by: 1.

Abstract. Liver fibrosis is defined as excessive extracellular matrix deposition and is based on complex interactions between matrix-producing hepatic stellate cells and an abundance of liver-resident and infiltrating cells. Investigation of these processes requires in vitro and in vivo experimental work in animals.

However, the use of animals in translational research will be increasingly Cited by: (cont.) Animal models of liver fibrosis / Marcos Rojkind and Patricia Greenwel -- Animal models of copper toxicosis / Michael L. Schilsky and Irmin Sternlieb -- Animal models in liver research: iron overload / Theodore C.

Iancu -- Portosystemic hepatic encephalopathy related with congenital and acquired hepatopathies in the dog / Jan Rothuizen -- Metabolic fatty liver of ruminants / Michael L.RESEARCH UPDATE Animal Models of Alcoholic Liver Disease—Focus on the Intragastric Feeding Model Amin A.

Nanji, M.D., and Samuel W. French, M.D. The use of animal models has contributed to greater understanding of how alcoholic liver disease (ALD) develops, and of how the severity of liver File Size: KB.